49ers at Cowboys: Week 10 NFL Odds, Prediction, and Best Bet

The San Francisco 49ers travel to Dallas on Sunday for a Week 10 NFL showdown airing on FOX.

Here are the current odds for Cowboys versus 49ers at FanDuel Sportsbook, as of November 15.

   49ers vs. Cowboys Odds

Moneyline

Spread

• 49ers -4.5: -108
• Cowboys +4.5: -112

Over/Under

• Over 55.5: -102
• Under 55.5: -118

   49ers vs. Cowboys: Prediction and Pick

Key Insights from FOX Sports Research:

• Both offenses rank among the top six in scoring in the NFL. San Francisco is third at 29.4 points per game, while Dallas is sixth at 27.3. The two teams combined for 54 points in their last meeting, a 30-24 victory for the 49ers.
• San Francisco leads the NFL with 6.3 yards per play and ranks second in third-down conversion rate at 51.7%. Dallas is fifth on third down (45.3%) and third in red-zone touchdown rate (71.4%).
• Brock Purdy and Dak Prescott have each thrown for at least one touchdown in every game this season. Purdy has five touchdown passes and zero interceptions in three head-to-head meetings with Prescott, who matched his season high with 335 passing yards last week.
• Christian McCaffrey and Javonte Williams each have 10 scrimmage touchdowns, a total reached by only five players this season. CeeDee Lamb ranks second in the NFL with 904 receiving yards, and George Kittle ranks third among tight ends with 483.

   Recommended Pick: Over 55.5

How to Watch Cowboys vs. 49ers

• Date: Sunday, Nov. 15, 2026
• Time: 4:25 p.m. ET
• TV: FOX
• Location: AT&T Stadium, Arlington, TX

Source link