The same chemical process that causes browning in baked goods also accelerates cellular aging in the body. Over time, tissues develop advanced glycation end products (AGEs) as sugars bind to proteins and fats in the bloodstream. These compounds stiffen collagen and trigger inflammation linked to conditions like diabetes and heart disease.
A newly engineered enzyme, CMLase, disrupts this cycle by breaking down AGEs already embedded in human tissues. This cleanses cellular structures, restoring flexibility and functionality. Preliminary tests on aged skin showed rejuvenation equivalent to reducing biological age by decades, according to lead researcher Aaron Cravens.
Developed through AI-driven analysis of microbial enzymes, CMLase was optimized to efficiently target AGEs. Unlike prior approaches that failed to inhibit AGE formation, this enzyme acts retroactively to repair damaged tissues. Its potential applications extend to eye diseases, kidney dysfunction, and cardiovascular issues caused by AGE accumulation.
While not a cure for aging, this breakthrough demonstrates how engineered proteins could address age-related pathologies. Journal co-author Michael Jewett highlighted the study’s ingenuity, calling it “a masterclass in enzyme engineering” with broad therapeutic implications.