Baseline aspartate aminotransferase-to-alanine aminotransferase ratios were linked with faster cognitive and cortical decline in 2,700 Alzheimer’s Disease Neuroimaging Initiative participants, especially among APOE4 carriers. (Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring)
Brain-gut crosstalk was associated with brain aging in healthy young and midlife adults, an imaging study of four cohorts showed. (eBioMedicine)
In a sample of social media posts about Alzheimer’s blood tests, more than a third discussed their usefulness for asymptomatic screening, inconsistent with guidelines. (Journal of the American Geriatrics Society)
A single neural implant simultaneously decoded speech and gesture brain signals from three paralyzed people. (Nature Neuroscience)
The FDA put new patient enrollment on hold in Biohaven’s pivotal trials of the investigational epilepsy drug BHV-7000, or opakalim, in response to metabolite findings from rodent tests. (Fierce Biotech)
Epilepsy occurred more frequently in children with a history of febrile seizures than in others and was associated with larger differences in academic test scores, a cohort study in Denmark showed. (JAMA Network Open)
The inflammatory consequences of stopping disease-modifying therapies in older multiple sclerosis patients were modified by age, with fewer effects seen in people ages 60 and older in a prospective cohort study. (Journal of Neurology, Neurosurgery & Psychiatry)
Lasker Award-winning sleep researchers illustrated how convergent approaches from their labs identified the orexin system as an essential wake-promoting neurotransmitter. (JAMA)
And actor Michael J. Fox, winner of the Lasker public service award, described how his foundation changed the face of research by bridging gulfs in the Parkinson’s disease community. (JAMA
Singer Celine Dion, who was diagnosed with stiff person syndrome in 2022, returned for her first full concert in more than 6 years. (AP)
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