Conference play takes center stage as College Football enters Week 4 with a marquee slate of matchups.
Six ranked clashes headline the weekend, headlined by No. 1 Texas traveling to face No. 14 Tennessee in Knoxville. Can Arch Manning deliver a statement performance on the road?
Big Ten action also ramps up, with defending national champion Indiana opening conference play Friday night on FOX against undefeated Northwestern, which dominated Colorado last week.
On “Big Noon Kickoff,” Ohio State welcomes Illinois for its Big Ten debut following an early loss to Texas. Meanwhile, No. 18 Michigan hosts No. 17 Iowa in a clash of two undefeated squads.
Elsewhere, Ole Miss looks to bounce back in Gainesville after an emotional win over LSU, while Lincoln Riley seeks a signature moment as USC hosts Oregon in Los Angeles.
A stacked Week 4 awaits. Here are our expert picks for the biggest games of the weekend.
2026 College Football Expert Picks Week 4
Ranked action kicks off Friday night with Northwestern visiting No. 5 Indiana (8 p.m. ET, FOX), followed by a heavy Saturday slate including Texas at Tennessee (noon ET, ABC) and Illinois at Ohio State (noon ET, FOX).
Texas-Tennessee, Michigan-Iowa, Oregon-USC, Ole Miss-Florida and more Week 4 Picks
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