In May, Republican voters in Louisiana delivered a decisive triumph to President Trump, ousting Senator Bill Cassidy at his behest.

On Saturday, voters will again decide on his preferred candidate, with polls closing at 8 p.m. local time in a runoff that will determine Cassidy’s successor in this deep‑red state.

Trump endorsed Representative Julia Letlow, who captured roughly 20 percentage points over Cassidy last month, though she fell short of an outright majority, triggering the runoff.

Letlow now faces State Treasurer John Fleming, a former congressman and longtime Trump ally who has positioned himself as the more conservative alternative.

Fleming trailed Letlow by about 17 points in May, leading many to anticipate an easy win for her; however, limited polling ahead of Saturday indicated the contest might be tighter.

Analysts noted that the race has evolved beyond a simple referendum on Cassidy, who angered Trump and his supporters by voting to convict him in the 2021 impeachment trial; it remains uncertain whether those voters will turn out again, according to Lionel Rainey III, a Louisiana Republican strategist.

“A Letlow loss would be inexplicable,” Rainey remarked, though “it is somehow possible,” he added.

The runoff victor will be a heavy favorite in the ensuing general election in Louisiana.

Key points to watch.

Cassidy’s defeat last month formed part of a series of spring victories for Trump, who also backed primary challengers who unseated Representative Thomas Massie in Kentucky and Senator John Cornyn in Texas.

While Trump’s endorsement has often proved a near‑guaranteed boost in certain GOP primaries, it faltered in others. This month, Republican primary voters rejected his candidates in Iowa and Georgia’s gubernatorial races, prompting Trump to adopt a more conciliatory dual endorsement in South Carolina.

In a recent interview, Fleming argued that the runoff dynamic had “completely changed,” noting that voters now say, “I’m backing the candidate who’s more Trump‑aligned, not the one with the endorsement.”

Letlow, 45, a former educator from Monroe, Louisiana, has a distinctive political trajectory; she had never previously contested a competitive race.

She first secured the seat in early 2021 after winning a special election to fill the vacancy left by her husband, Luke Letlow, who had been elected in November but died of Covid‑19 complications before taking office.

Trump encouraged her to run for the Senate seat — posting “RUN JULIA RUN!!!” on social media in January — and has since championed her candidacy.

She has also received support from Governor Jeff Landry, Attorney General Liz Murrill, and House Majority Leader Steve Scalise, all prominent Republicans in the state.

A defeat for Letlow on Saturday would send a “jolt” through Louisiana’s Republican establishment, warned Robert Hogan, a political science professor at Louisiana State University, though he cautioned that unusually low turnout could still allow an upset.

Since his primary loss, Cassidy — historically mild‑mannered — has adopted a more confrontational tone.

He engaged in a shouted exchange with Trump on Capitol Hill and has posted pointed social‑media critiques of the president regarding the fragile Iran agreement.

Cassidy has not endorsed any runoff candidate, and some Louisiana Republicans are monitoring his social‑media activity on Saturday, especially if Trump’s chosen candidate falters.

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